Non-communicable diseases (NCDs) are the leading cause of mortality worldwide, disproportionately affecting low-and middle-income countries (LMICs) and US Tribal populations. Multi-modality management, which integrates various therapeutic strategies, is essential for effective NCD control in these settings. This Study explores implementation research methodologies to enhance multi-modality management of NCDs, focusing specifically on sleep disorders and mental health research. Through comprehensive analysis, the paper provides actionable recommendations for policymakers, healthcare providers, and researchers to improve health outcomes in these vulnerable populations.